Blog · HPLC Tutorials

Practical guides written by analytical chemists. No filler theory — the key concepts, the method decisions, and the common problems that show up in a real lab.

Troubleshooting 8 min read

Why do HPLC peaks tail? Causes and fixes

Peak tailing is the #1 problem in liquid chromatography. Learn to pin down its cause — active silanols, column overload, dead volume, the wrong pH — and the specific fix for each, with the USP tailing factor as your diagnostic.

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More English tutorials coming soon — gradient vs isocratic, comparing C18 columns with the HSM model, and method development walkthroughs.